2022’s Top 5 Joint Health Supplements

Did you know that most Joint Health Supplements don’t work? We’ll help you find the right one that does.

Sarah Connely

Dr. Sarah Foster is a certified MD and health coach based in St. Petersburg, Florida. When she isn't researching health products, Sarah enjoys exploring local farmers markets and growing her own non-gmo vegetables

Millions of people in the United States Suffer from chronic pain. Friction develops in our joints as we get older, and is worsened by being active or carrying excess weight. According to the CDC, around one in four adults experience severe joint pain.

That’s why so many are turning to joint health supplements as an effective way to improve their flexibility, aches, pain, and alleviate overall joint discomfort. Yet, if you do decide to try a joint health supplement, how do you know which one will deliver results?

Skip to #1 Ranked Joint Health Supplement *

Intelligent Reviews has compiled years of research on Joint Health Supplements. We’ll show you what to avoid, what to look for, and which ingredients can help transform your life.

Scientific studies have found that the right Joint Supplements may help you in the following ways:

Alleviate joint discomfort , and improve mobility and flexibility .

Help comfort joints starting in as little as 5 days, and continuing with consistent use.

Help increase walking distance and speed.

Help support functional performance of joints.

Helps support range of motion.

Help support cartilage and connective tissue health.

How The Right Supplements Promote Joint Mobility & Flexibility

Many factors affect mobility—such as weight, age, activity, and even stress. Fortunately, certain quality vitamins found in top joint health supplements can address everyday discomfort from several of these key angles.

“Steven Sinatra, M.D. proclaims “Most MD’s now realize that all conventional painkillers, arthritis drugs and NSAIDs (including aspirin) BLOCK your body’s natural ability to heal the root cause of pain.”

Top Joint-Boosting Ingredients To Look For
(What You Absolutely MUST Avoid)

There are plenty of joint health supplements on the market today that promise to improve joint health and alleviate aches and other issues. But, with so many empty promises in the supplement industry, it’s hard to know which joint vitamins will deliver relief... and which will leave you disappointed.

We've done the work for you and compiled a review containing our top 5 choices for joint health in 2022, including a helpful guide for what to look for and what to avoid in joint health supplements.

Our Intelligence Reviews team of Physicians, MD’s, and PHD’s have done the work for you and compiled a review containing our top 5 choices. In addition to a detailed guide, we’ll show you what to avoid and what you need in a joint health supplement, and how it can help you restore your health.

The Benefits Of Joint Support Supplements With Clinically Studied Ingredients

  • They are the most scientifically sound way to target and eliminate joint stiffness and mobility issues naturally.
  • Clinical Studies show that they help the body prevent further joint and cartilage damage, and they can actually reverse damage that has already occurred.
  • Proven to naturally reduce joint swelling, maintain blood supply to inflamed joints, and increase mobility as well as reduce Pain due to stiffness in the joints.
  • These ingredients help increase the production of anti-inflammatory cells in your joints, leading to less pain.
  • These ingredients have been tested and proven to provide deep pain relief without the use of prescription medication that do more to mask the pain than heal it.
  • They are an effective and safe option for treating mobility related pain and stiffness + joint aches, cramps, and inflammation related issues.
Supplements that are clinically proven to reduce inflammation include:
  • Turmeric Curcumin (95% or higher)
  • Omega-3’s DHA/EPA
  • UC-II Collagen
  • NEM®Natural Eggshell Membrane
Supplements that are clinically proven to decrease pain & stiffness include:
  • Hyaluronate
  • Ginger Root
  • Black Pepper Piperin
  • White Willow
Supplements that are clinically proven to boost mobility include:
  • Elastin
  • Curcumin Tumeric
  • Calcium
  • Vitamin C

These nutrients have been clinically proven to improve mobility,rebuild broken down cartilage,promote cognitive health, enhance athletic performance,and support overall health.

Non-GMO, gluten-free, no harmful fillers.

Top Clinically Proven Ingredients To Look For:

  • Boswellia – has been known to reduce joint swelling, maintain blood supply to inflamed joints, and increase mobility as well as reduce pain due to stiffness in the joints. By naturally regulating the body’s inflammation response, this healing tree extract is clinically proven to improve joint stiffness and swelling in as little as weeks to months.
  • Tumeric – Also known as Circumin, this comes from a spice grown in India. It has been used successfully for over 4,000 years to reduce or end pain. Dr. Randy J. Horwitz wrote in the American Academy of Pain Management “Turmeric is one of the most potent natural anti-inflammatories available,” It lowers the levels of two enzymes in the body that cause inflammation.
  • NEM® Natural Eggshell Membrane – A clinically studied source of joint- supporting collagen Types I, V,=, and X. Eggshell Membrane received a top score for pain relief & has been clinically proven to reduce inflammation, swelling, and joint pain. Collagen found in Eggshell membrane have been clinically studied for their ability to enhance cartilage regeneration by inhibiting the break down of enzymes found in cartilage tissue. The collagen found only in eggshell membrane gets to the core source of joint aches, pains, and stiffness - naturally. Make sure to search for NEM® and not regular “eggshell membrane” which can be synthetic and dangerous.
  • Hylaronic Acid – Also known as Hyaluronate, is a key building block of the body’s “natural joint fluid” medically known as synovial fluid. This joint fluid reduces friction in the joints allowing for effortless motion. Clinical research has shown that Hylaronic acid is one of the most powerful reliever of joint discomfort and stiffness.
  • UC-II Collagen – UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. In fact, in vitro studies have shown that many of the cytokines implicated in the onset and progression of both rheumatoid arthritis. In a randomized, double-blind, placebo-controlled study, subjects in the UC- II group exhibited a statistically significant improvement in average knee extension compared to placebo.
  • Omega-3 EPA/DHA – Omega-3 fatty acids EPA/DHA (eicosapentaenoic acid, docosahexaenoic acid): act as anti-inflammatory agents. In addition they provide substantial amounts of Vitamin D, which is necessary for proper bone growth and function.

What To Avoid:

  • Glucosamine & Chondroitin – Two hugely popular supplements used to fight arthritis and joint pain, glucosamine and chondroitin sulfate, do not seem to work any better than placebo to slow the loss of cartilage. The study, funded by the National Center for Complementary and Alternative Medicine at the National Institutes of Health, confirms other findings showing the supplements have few or no effects.
  • MSM – The Arthritis Foundation states that there are currently no large, well- controlled studies on MSM. Since little is known about the long-term safety of MSM , it's no surprise that the efficacy also is unclear
  • Joint Pain Topicals – While joint pain topicals may fix pain momentarily, they do not get to the root issue of damaged or inflamed joints. These should be only seen as a immediate solution, and not a long-term fix.
  • Amazon Reviews – According to a recent study by the New York Times, up to 60% of all Amazon Reviews have been paid for. Do your research before buying a suspiciously high rated or cheap supplement. Many companies have been caught red handed paying individuals to leave positive reviews, regardless of their experience.


We’ve compiled a list of what we’ve found to be the top five products in this category, on the market today.

Grade A+

1. Arthrogenix

by Alpha Vita
Total Ranking 9.7/10
Total Ranking
A+ Overall Grade


  • Impressive Clinical Results
  • 100% Wildcrafted for Maximum Absorption
  • 120 day Money Back Guarantee
  • 14 Peer Reviewed Ingredients with Optimal Dosages
  • Includes JointGaurd® Boswellia, UC-II Collagen, Omega-3s, & Eggshell Membrane
  • 96% Positive Customer Feedback
  • Formulated by Respected Board-Certified MD
  • No Binders, Fillers, or Synthetic Ingredients
  • Rated #1 By the N.H.F


  • Sold Out Regularly
  • Expensive

The Bottom Line

Arthrogenix® is a standout #1. This premium supplement has received outstanding global recognition for its comprehensive, clinically studied formula. Clinical studies prove it reduces pain and stiffness and improves flexibility in just 7 to 10 days.

One example is a landmark study out of Europe. In the study the active ingredient in Arthrogenix was compared to NSAID pain reliever. The results were incredible! After just 30 days, more than 8 out 10 people who took Arthrogenix active ingredient had no swelling, in contrast, 9 out of 10 people taking the NSAID still had severe swelling.

The new wildcrafted delivery system for this product has caught the attention of many leading medical doctors. Amazing feedback from users of Arthrogenix has generated a wave of confidence at the company. So much so that they now offer a 120 money back guarantee.

Arthrogenix is the top formula for a reason, it is chock-full of potent nourishment that’s scientifically proven to give you significant and safe results in the shortest time possible.

Intelligent Reviews was able to locate an impressive 2022 survey on this product:

  • 91% customer satisfaction**
  • 98% who switched to Arthrogenix® said it was best joint supplement they've tried *
  • Over 82% reported improvements in swelling, discomfort, aches and tenderness Finally, Arthrogenix backs up every purchase with an impressive 120-day money-back guarantee. Between its comprehensive, doctor-made formula and outstanding customer satisfaction, Arthrogenix® is a standout #1.

*Result is based on the Intelligent Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit the product website for more information.

Grade A

2. Instaflex

by Essential Elements
Instaflex Joint Support
Total Ranking 9.0/10
Total Ranking
A- Overall Grade


  • Pain Reliever Features UC-II Collagen + ApresFlex Boswellia
  • Pain Reliever Features UC-II Collagen + ApresFlex Boswellia
  • Formulated by Respected MD
  • Complementary ingredients
  • Supports overall joint health


  • Lacks Eggshell membrane and other premium ingredients
  • May lack components that increase efficacy.
  • Mixed customer reviews

The Bottom Line

Instaflex was our second choice because of its well-sourced and complementary ingredients.It contains a clinically recommended amount of Boswellia, and UC-II Collagen the two most clinically proven ingredients on the market.

These ingredients work well together in strengthening and maintaining bone health through the stimulation of proteins and the absorption of calcium.

In short, our experts have chosen Instaflex as the #2 in the list because of its remarkable effectiveness and optimal dosage.

*Results are based on the Intelligent Reviews Rating System, and do not necessarily reflect typical results from the use of these products. Please visit websites for each product for more information.

Grade B+

3. Relief Factor

 Relief Factor
Total Ranking 8.9/10
Total Ranking
B+ Overall Grade


  • 100% drug-free supplement
  • May protect joints from damage and reduce pain
  • Comes in convenient, individual packages
  • Formulated with clinically researched ingredients


  • Difficult return policy
  • No third-party testing

The Bottom Line

Relief Factor is designed to help alleviate joint pain associated with exercise, aging, and everyday living. The formula is 100% drug-free and made with icariin, turmeric, resveratrol, and omega-3 to support your body’s natural healing process and help reduce pain and inflammation.

The company offers a three-week trial for just $19.99 (plus S&H). After that, your subscription automatically renews at a higher cost of $79.99 each month until canceled.

*Results are based on the Intelligent Reviews Rating System, and do not necessarily reflect typical results from the use of these products. Please visit websites for each product for more information.

4. Osteo Bi Flex

 Osteo Bi Flex
Total Ranking 8.7/10
Total Ranking
B+ Overall Grade


  • Diverse Ingredient profile
  • Uses Clinically Studied form of Boswellia not Generic


  • Lacks UC-II Collagen, Eggshell membrane, and other premium ingredients
  • May lack components that increase efficacy.
  • Return Policy is not Risk-Free
  • Lacks some essential ingredients
  • Contains Glucosamine, Chondroitin, and MSM

The Bottom Line

This was one of the only products we could verify had no hidden additives or artificial ingredients. It was also one of the only collagen supplements third-party tested.

Their return policy was topnotch — a comprehensive 60-day, risk-free, money-back guarantee proving the company stands behind its products.

This was a huge advantage versus the competition, along with total effectiveness projections that rivaled any other supplement we found.

*Results are based on the Intelligent Reviews Rating System, and do not necessarily reflect typical results from the use of these products. Please visit websites for each product for more information.

5. NOW Foods UC-II

Total Ranking 8.5/10
Total Ranking
B- Overall Grade


  • Pain Reliever Features UC-II Collagen
  • Good Value
  • Positive reviews


  • Only available online
  • Sometimes runs out of stock
  • Lacks many essential components that increase efficacy.

The Bottom Line

Now Foods products are often hit or miss. Luckily this time the “UC-II, Undenatured Type II Collagen” product is well worth the price.

Cartilage is one of the primary connective tissues of the body, providing flexibility and support to bone joints. Undenatured Type II Collagen is the principal structural protein in cartilage that is responsible for its tensile strength and toughness.

*Results are based on the Intelligent Reviews Rating System, and do not necessarily reflect typical results from the use of these products. Please visit websites for each product for more information.